The Primordial Code
summary
Cells behave like messy computers: DNA stores information in 3 billion base pairs per human, genomes fall from millions to a cost under $1000 to sequence, and evolution edits code via substitutions, duplications and plasmid transfer. Examples land concrete: ATP synthase is a literal rotating motor, mitochondria act like containerized OS instances, labs build yeast deep-mutational scan libraries of every one-letter G6PD variant to measure survival, and pseudouridine-modified mRNA vaccines (Catalyn Caraco) move past cellular filters and work.
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chapters (12)
- 0:00Introduction to bioinformatics
- 2:13What is bioinformatics
- 6:44Biology crash course
- 13:08Genes, evolution, mutations
- 16:40Central dogma explained
- 20:14Gene regulation and code
- 22:44Endosymbiosis and cellular encapsulation
- 25:32Bioinformatics in medicine
- 26:56Yeast experiments and mapping
- 29:24Debugging biology
- 30:47mRNA vaccines and science
- 32:13Open science future
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