Allen Institute Large-scale Datasets and Modeling Tools
summary
Allen Institute provides large public datasets and runnable models: ~100 mouse cortical cell types from ~20,000 sequenced cells and 45,000+ recorded cells in the Allen Brain Observatory, patch‑clamp plus Patch‑seq linking morphology/ephys/transcriptomics, and multi‑patch synaptic physiology (up to 8 cells) to measure connection probabilities and short‑term dynamics. They build a 10,000‑neuron layer‑4 biophysical model (trained by tuning ~20 synaptic weight groups) that reproduces firing rates, orientation tuning and gamma band power but misses direction selectivity; reduced point‑neuron versions track trends but lose oscillations. Data, NEURON‑based models and APIs are on GitHub and public servers.
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