Jonathan Stark interviewed at OSCON 2010
summary
HTML/CSS/JavaScript works well for content-heavy apps and rapid iteration while native code suits immersive games; distribution via URL and broad WebKit coverage speed deployment and make testing with hundreds or thousands feasible where Apple betas are limited. PhoneGap is a thin wrapper that exposes camera, accelerometer and contacts APIs so JavaScript can use device hardware. App Inventor lowers barriers but does not let you export source code, which blocks extending prototypes into full apps.
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