Pathways, Centrality, and Regulation in Developmental Disorders

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" summary

Defines pathway centrality as all-pairs shortest-path betweenness from GWAS/disease genes to differentially expressed genes on PPI and directed regulatory networks, then scores gene sets (GO, MPO) by group betweenness and tests significance by sampling the network 2-core degree-matched sampling. Finds immune/inflammation hits across BPD, asthma, COPD, plus specific candidates: NF-κB mediation, insulin-receptor signaling, and disrupted vasculogenesis and bone ossification in BPD. Builds a partial least squares age-prediction per-pathway to flag temporal dysregulation; experiments for validation are ongoing.

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" chapters (22)

1. 0:00Intro
2. 0:41Molecular Causes of Prematurity Complications
3. 3:30Betweenness Centrality and Bottlenecks in Molecular Networks
4. 4:48Group Centrality in Molecular Networks
5. 6:25Pathway Centrality in Disease Networks
6. 7:41Our Data Sets
7. 9:53Disease Genes
8. 10:41Differential Expression
9. 11:40Assessing significance
10. 13:03PPI Results: Common GO Processes
11. 13:42Regulatory Network Results: GO
12. 16:14PPI: Common MPO Phenotypes
13. 16:27Some new observations
14. 17:29Down syndrome controls
15. 18:22BPD: developmental delays?
16. 19:26BPD: abnormal vasculogenesis
17. 22:50TEMPO: finding developmental dysregulation of expression
18. 25:07Developmentally inappropriate expression of vasculogenesis pathway in BPD
19. 25:50Developmentally inappropriate expression of ossification pathway in BPD
20. 26:13Vasculogenesis in BPD
21. 27:22Conclusions
22. 27:42Acknowledgements

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