Hacking the Human Genome Using Clojure and Similarity Search

on YouTube ↗31m

" summary

Uses Clojure pipelines to slide windows over multispecies alignments, compute Hamming-distance fingerprints and conservation, then apply similarity search plus clustering to propose transcription-factor motifs. Implements one-class SVMs and hybrid filters to rank and de-duplicate millions of candidates, returning motif logos and syntax rules for promoters. Claims recovery of about 81% recall on known TFs and produces ranked novel binding-site predictions, demonstrating a working end-to-end discovery pipeline.

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" chapters (7)

1. 0:00Start
2. 3:01iPS: induced pluripotent stem cells
3. 5:00Transcription Factors attach
4. 12:11Similarity Search Definition
5. 13:12Example: Hamming Distance
6. 16:02Distance Function Example
7. 23:58Post-processing

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